The active ingredient formulation in BioSela-EAA given for 60 weeks to elderly subjects with type 2 diabetes resulted in decreased fasting blood sugar, post-prandial glucose, HbA1c, and serum insulin, and improved insulin sensitivity.
Solerte SB, Fioravanti M, Locatelli E, et al. Am J Cardiol 2008;101:82E-88E.
The active ingredient formulation in BioSela-EAA given for a period of six months and 18 months in elderly subjects resulted in significant increase in whole-body lean mass; significant decrease in fasting blood glucose and serum insulin; improved insulin resistance; significant reduction in serum tumor necrosis factor-alpha; and a significant increase in IGF-1 and in the IGF-1/TNF-alpha ratio.
Solerte SB, Gazzaruso C, Bonacasa R, et al. Am J Cardiol 2008;101:69E-77E.
The active ingredient formulation in BioSela-EAA increases muscle mass by stimulating muscle fiber hypertrophy and improving strength.
Kraemer WJ, Ratamess NA, Volek JS, et al. Metabolism 2006;55:282-291.
Twelve weeks of the active ingredient formulation in BioSela-EAA given to elderly subjects improved walking capacity, muscle strength and heart function.
-Scognamiglio R, Testa A, Aquilani R, et al. Am J Cardiol 2008;101:78E-81E.
Supplementation with the active ingredient formulation in BioSela™-EAA for three months in COPD patients improved blood oxygen, cognitive function, general health status, and muscle energy metabolism.
-Dal Negro RW, Aquilani R, Bertacco S, et al. Monaldi Arch Chest Dis 2010;73:25-33.
Cancer patients with cachexia (stage IV): Twenty five individuals given the active ingredient formulation in BioSelaTM-EAA one sachet twice daily for eight weeks demonstrated significant improvement in grip strength, serum albumin, and ROS. C-reactive protein reduced from 25 to 17. Patients gained an average of 2.4 lbs during the eight-week trial.
-Madeddu C. Mediterr J Nutr Metab 2010;3:165-172.
Thirty days of supplementation with the active ingredient formulation in BioSela-EAA in elderly subjects with chronic heart failure (CHF) improved exercise capacity, oxygen utilization and muscle function.
-Aquilani R, Viglio S, ladarola P, et al. Am J Cardiol 2008;101:104E-110E.
The latest research proved that the active ingredient formulation (Vitamin E) in BioSela™-EAA as a single isomer or in combination can reduce the risk of age related muscle atrophy (Sarcopenia).
Oxidative and cellular longevity volue 2014, article Id 914853, Author Shy Cian Khor, etal.
The studies have proved that the active ingredient formulation (Vitamin D) in BioSela-EAA reduces the risk of COPD and COPD exacerbation.
Ampikaipakan,S.N.Hughes, D.A. Hughes, J.C.Amen,T.Bentham, G.Wilson.Thorex.2010 jun 26
The studies have shown that the active ingredient (Vitamin C) in formulation BioSela™-EAA has a significant reducive effect on ROS and Pro-inflammatory cytokines which ultimately increases the body lean mass.
Cancer EpidemolBiomarker prev.2004 oct 13(10):1651-9.
Blueberries (fruits of various Vaccinium species) are among the fruits with high antioxidant power and rich in anthocyanins
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Blueberries are rich in flavonoids, which possess antioxidant and anti-inflammatory properties. Flavonoids encompass a range of sub-classes including anthocyanins, flavonones, flavanols, flavonols, flavones, isoflavones and proanthocyanidins that possess in vivo anti-oxidant and antiinflammatory properties. High flavonoid intakes attenuate age-related cognitive decline, but data from human intervention studies are sparse. Chronic supplementation with blueberry concentrate providing 387 mg anthocyanins per day exerted favourable effects on cerebrovascular and cognitive function in healthy older adults.
Specifically, resting state perfusion in the gray matter of the parietal and occipital lobes and brain activation in a number of task-related different areas, increased from baseline levels after 12 weeks of blueberry supplementation Acute consumption of blueberry polyphenols (0.3-1.88 g) has been shown to increase endothelium dependent vasodilatation in the brachial artery, blueberry supplementation in the present study, blueberry concentrate consumed once per day (30 ml, providing 387 mg anthocyanins) for 12 weeks increased activation of brain areas associated with cognitive processes including memory and executive function, which tend to deteriorate with age.
These effects of blueberry appear to be mediated by improved vascular function as suggested by the improved resting perfusion of gray matter in the parietal and occipital lobes of the brain.supplementation with the blueberry extract concentrated in polyphenols, is closely related to higher brain antioxidant properties and inhibition of AChE activity. These findings stress the critical impact of wild blueberry bioactive components on brain function.
Bowtell JL, Aboo-Bakkar Z, Conway ME, Adlam AR, Fulford J. Enhanced task-related brain activation and resting perfusion in healthy older adults after chronic blueberry supplementation. Appl Physiol Nutr Metab. 2017 Jul;42(7):773-779. doi: 10.1139/apnm-2016- 0550. Epub 2017 Mar 1. PMID: 28249119.
Papandreou MA, Dimakopoulou A, Linardaki ZI, Cordopatis P, Klimis-Zacas D, Margarity M, Lamari FN. Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity. Behav Brain Res. 2009 Mar 17;198(2):352-8. doi: 10.1016/j.bbr.2008.11.013. Epub 2008 Nov 17. PMID: 19056430.
Docosahexaenoic acid (DHA) is an n-3 fatty acid that has gained increased attention over the last 20 years in pregnancy and lactation for its role in brain development, as it accounts for over 10% of brain fatty acids and is essential for infant development. the infant brain doubles in weight, and the large brain to body weight ratio for infants (0.1) compared with adults (0.02). DHA from the maternal diet is a more efficient source of neural tissue DHA than an equivalent amount of ALA, given that less than 10% ALA is converted to DHA.
Sherry CL, Oliver JS, Marriage BJ. Docosahexaenoic acid supplementation in lactating women increases breast milk and plasma docosahexaenoic acid concentrations and alters infant omega 6:3 fatty acid ratio. Prostaglandins Leukot Essent Fatty Acids. 2015 Apr;95:63-9. doi: 10.1016/j.plefa.2015.01.005. Epub 2015 Feb 11. PMID: 25701002.
While EPA is great for helping lower chronic pain and inflammation anywhere in the body, DHA is best for the brain. In fact, studies show consuming high ratios of DHA help with depression, mood swings, bipolar symptoms, poor memory, cognitive decline, and other brain-based disorders .
If you want to support brain health, your essential fatty acid supplement should have at least a ratio of 4:1 of DHA to EPA. However, contact my office if you’re interested in one that has a 24:1 ratio. Ample DHA in the brain ensures neurons are sufficiently fluid and flexible, which is necessary for them to communicate with one another. Good communication between neurons is foundational to healthy brain function, good cognition, a brain that is calm and alert, for proper brain development in children, and for healthy brain aging in adults. DHA also inhibits brain degeneration.
DHA has also been shown to improve both short-term and long-term memory and reduce brain inflammation. Reducing brain inflammation is important because this is at the root of so many common problems, including depression, fatigue, memory loss, and brain fog. Brain fog is also serious because it speeds aging of the brain and raises your risk of dementia and Alzheimer’s.
https://thefnc.com/research/the-best-fat-for-your-brain-dha-in-fish-and-algae-oil/
Important component of brain cells.
This paper discusses the effects of curcumin on patients with Alzheimer's disease (AD). Curcumin (Turmeric), an ancient Indian herb used in curry powder, has been extensively studied in modern medicine and Indian systems of medicine for the treatment of various medical conditions, including cystic fibrosis, haemorrhoids, gastric ulcer, colon cancer, breast cancer, atherosclerosis, liver diseases and arthritis. It has been used in various types of treatments for dementia and traumatic brain injury. Curcumin also has a potential role in the prevention and treatment of AD. Due to various effects of curcumin, such as decreased Beta-amyloid plaques, delayed degradation of neurons, metal-chelation, anti-inflammatory, antioxidant and decreased microglia formation, the overall memory in patients with AD has improved.
The effect of curcumin (turmeric) on Alzheimer's disease: An overview Shrikant Mishra and Kalpana Palanivelu
Curcumin holds a high place in Ayurvedic medicine as a “cleanser of the body,” and today, science is finding a growing list of diseased conditions that can be healed by the active ingredients of turmeric.
Synthesis and antitumor activity of some curcumin analogs. Youssef KM, El-Sherbeny MA Arch Pharm (Weinheim). 2005 Apr; 338(4):181-9.